Category Health and Medicine

When vaccination was born

On May 14, 1796, Englishman Edward Jenner tested vaccination on a human subject. Building on conventional wisdom, Jenner introduced vaccination against smallpox, a disease that has now been eradicated.

You probably already know this story. Yes, you read that right. When the world was gripped by the COVID-19 pandemic, the race to find a vaccine dominated news across the globe. And among the countless vaccination related stories, the story of Englishman Edward Jenner also found mention on occasions. But considering that we have collectively forgotten a lot of good that we learnt during the height of the pandemic, you wouldn't be judged if you have forgotten Jenner’s story too.

Born in Berkeley, Gloucestershire on May 17, 1749, Jenner was the eighth of nine children born to the vicar of Berkeley, the Reverend Stephen Jenner, and his wife Sarah. He was apprenticed to a local surgeon at the age of 14 and then trained in London. Returning to Berkeley in 1772, he spent much of his career as a doctor in his native town.

Cowpox doesn't kill

During his time as a medical student, Jenner observed that milkmaids who had contracted a disease called cowpox, which caused blistering on cow's udders, did not catch smallpox. While cowpox led to few ill symptoms among these women, smallpox caused severe skin eruptions and high fevers among humans. Believed to have existed for thousands of years, smallpox was one of the most devastating diseases known to humanity and killed millions through the centuries.

Jenner decided to put the conventional wisdom into practice and devised an experiment. On May 14, 1796, Jenner took fluid from a cowpox blister on milkmaid Sarah Nelmes. He inserted the pus taken into an incision on eight-year-old James Phipps' arm.

The eight-year-old experimental subject fell mildly ill with cowpox a few days later, but was well again a week later. While this helped Jenner learn that cowpox could pass from person to person as well as cow to person, his next step was to find out if the experiment would protect Phipps from smallpox.

Ethical debate

Starting on July 1, Jenner repeatedly inoculated Phipps with smallpox matter. While ethicists now debate if such an experiment would be possible today, it was possible in Jenner’s time. And to his relief, the boy, who had been inoculated with cowpox, was now immune to smallpox, just as he had anticipated.

Having succeeded at what he set out to do, Jenner submitted a paper describing his experiment to the Royal Society in 1797. His revolutionary ideas weren't immediately accepted and he was asked for further proof.

Not one to be daunted, Jenner experimented with several others and in every case he was unable to infect them with smallpox if he had vaccinated them, or if they had contracted cowpox earlier naturally. He published all his research in 1798 in a book entitled "An Inquiry into the Causes and Effects of the Variolae Vaccinae; a Disease Discovered in some of the Western Counties of England, Particularly Gloucestershire, and Known by the Name of The Cow Pox". It was Jenner who coined the word "vaccine" from the Latin vacca for cow.

Efficacy wins over people

Jenner was still ridiculed, especially by clergymen, who saw his method of inoculating someone with material from a diseased animal as ungodly and even repulsive. The advantages of vaccination and the protection it offered against smallpox eventually trumped the naysayers, and vaccination slowly caught on.

Having become famous, Jenner was able to spend more time researching and offering developments in his vaccine. He carried out research in certain other areas of medicine as well. He died on January 26, 1823.

Jenner's model was adopted by scientists in the centuries that followed, helping them develop vaccines to numerous deadly diseases. As for smallpox, it was declared eradicated in 1980 by the World Health Organisation following a global vaccination programme. The disease that led to the birth of vaccination is also the only infectious disease to achieve this distinction.

Picture Credit : Google 

It is widely used as a substitute for coffee or a coffee addictive as it balances its flavour and reduces its acidity. It is actually a perennial plant with purple-blue flowers. Its leaves are popular as salad greens and its long thick tap root is dried, cut and brewed for use in coffee or as a beverage by itself.

It adds aroma to the coffee blend and makes it thicker. It is caffeine-free and said to have health benefits. It cleanses the blood and kills bacteria in the liver and digestive tract.

It has been in use from the Middle Ages when Egyptians, Romans and Greeks used it as a herbal drink.

However, the tasty modern brew was developed by the French who found it was a good substitute for coffee which was scarce at the time.

Picture Credit : Google

Giddiness occurs when we lose our sense of balance. The sensations perceived by the eye, inner ear, skin, muscles and joints help the body to know its stability. Several unusual situations, such as travelling in a bus or looking down from a great height, over stimulate and confuse that part of the brain which controls balancing. (This is very close to the part which induces vomiting). When we look down from a great height, abnormal visual signs transmitted to the brain, without any corresponding information from other parts of the body. Likewise, while looking out in a fixed direction while travelling in a bus, the eye sends fast changing visual signals to the brain. Such signals confuse the mechanism in the brain and lead to giddiness and vomiting.

The question of why our temperature goes up during illness can be split into two parts. First, you need to know what makes the temperature go up, and secondly, what advantage an increase in temperature offers.

 The increase in core temperature observed during illness is commonly called fever and occurs in response to infection by a pathogenic organism or certain types of physical injury.

For example, when a person becomes infected with bacteria, the white blood cells of the immune system recognize the incoming pathogen as foreign and initiate the first stages of the immune response – the acute phase. In this reaction, white blood cells called monocytes release a variety of proteins called cytokines. These are central to the immune and inflammatory response.

In particular, there is a predominance of two types of cytokine called interleukin-1 (IL-1) and tumour necrosis factor-alpha. These cytokines are known as pyrogenic because they cause an increase in body temperature. It is not clear how they induce fever, but it is known that they also cause the production of other chemicals in the brain. The main groups of chemicals produced in this effect are the prostaglandins. These react very strongly with the hypothalamus area of the brain, which then sends a signal to the body to increase the temperature.

The mechanisms that the brain employs to affect this are not certain but are known to include increasing the metabolic rate and including shivering. These two processes burn metabolic fuel faster than normal and body heat is given off. The question of what advantage fever confers is interesting.

 Experimental work shows that the mortality of animals decreases if the fever is untreated, that elevated temperatures can enhance certain aspects of the immune response. Furthermore, the growth rates of various types of   bacteria are slowed at temperatures above normal body temperature. Indeed, the ancient Greeks believed that fever was beneficial; even in this century fever has been used to treat certain illness. For example, syphilis used to be notoriously difficult to treat, so doctors gave their patients malaria which fought the syphilis knowing that they could get rid of the malaria later.

Continue reading “Why does our temperature go up when we are ill?”

In the human body the mechanism is such that the oxygen we breathe in and the vital nutrients in the food that we eat are absorbed by the blood and supplied t the different organs.  This job is accomplished efficiently by about 5 litres of blood that circulate in a normal adult.

The amount of blood supplied to each organ depends on the oxygen and nutrition requirement of the tissue of the organ and the importance of the function it plays at any given time.

 Under normal conditions, the liver receives about slightly less than one-third of the blood that the heart pumps. Likewise, the kidneys get about one-fourth, and brain about one-sixth. The remaining goes to the muscles and other parts of the body. These quantities change depending on the body work and needs.

When we eat, the food needs to be digested and the nutrients absorbed by the blood. That is the focus of the work shifts to digesting the food and so more blood is sent to the stomach walls. Automatically the flow of blood to other parts of the body, including the brain, is reduced.

Only a few other very important functions like the functioning of the heart and lungs are continued. Once the blood flow to the brain is reduced, the body becomes lethargic and sleep sets in. So, better take a nap alter meals, it is only natural.

Researchers at the Chennai Institute of Magneto biology, say that sleeping in the  north-south direction could make one lack a sense of well being at times. According to Dr. Sankaranarayanan, director of the institute, when a man lies with his head towards north in pulsating magnetic field, his brain’s electrical activity is suppressed or damped. Measurement reveals that blood circulations in fingertips are affected and the balance between neuro-chemicals is upset. In addition, it gives subjective experiences like headache, confused thinking and lack of a sense of well-being.

As opposed to this, he says, if one sleeps east-west, in the pulsed field, the brain’s activity is considerably enhanced. Also, the peripheral blood circulation all over the body is enhanced. Hence he feels relaxed and alert.

It is known that the Earth’s magnetic field pulses at extremely low frequencies and is typically in the range of human brain’s electrical activity. These pulses are not present always but they peak during certain periods generally associated with solar activity. If one sleeps north-south during such activity headache, general discomfort, nausea and confusion may result. On inactive nights, there may not be any change in the body, he says. This is true for animals also as they are more sensitive to such changes.

Somnambulism is a psychiatric sleep disorder termed under ‘parasomnia’. Parasomnia, a disorder of transition from one sleep stage to another (arousal or partial arousal) can be marked by bizarre or sensual behaviour. Sleep is basically defined as that stage of unconsciousness from which the person can be aroused by sensory stimuli. Sleep can be broadly classified into two types, the slow wave sleep (Non-REM) and the Rapid Eye Movement (REM).  Normally the sleep that one gets is of the slow wave type. This is the deep restful type of sleep experienced in the first hour of sleep, in which the consolidation of the dreams in memory does not occur.

However a normal night of sleep, bouts of REM sleep lasting 15-30 minutes usually appear on the average of every 90 minutes, the first such period occurring 80-100 minutes after the person falls asleep. It is usually associated with active dreaming.

 The brain is highly active in REM sleep. Despite the extreme inhibition of the peripheral muscles, a few irregular muscle movements’ in particular rapid movements of the eye occur.

In the case of Non-REM sleep, the brain waves are very slow. But in the REM type of sleep the eyes undergo rapid eye movements despite the fact that the person is still asleep.

Sleepwalking, somnambulism, is the disorder of the non REM stage of sleep. It is the automatic execution of a sequence of complex behaviours that may include dressing, eating or bathroom visits as well as walking while asleep. It is a fairly common occurrence in childhood and adolescence, but may signify psychological disturbances in adulthood. The frequent episodes of which, more often experienced of which more often experienced by boys has its onset typically between 6-12 years of age.

Sleepwalking usually disappears after adolescence, but many reappear in the 3rd or 4th decade. There seems to be a heredito familial trend. The disorder has been associated with epilepsy, CNS infections and traumas, genito urinary complaints, psychopathology, sleep talking, nocturnal eneuresis and nightmares.

The treatments include besides other things education and appropriate sleep habits, avoiding sleep deprivation and compensatory slow wave sleep rebound by providing guidelines for a regular sleep wake schedule, taking day time naps to decrease pressure for slow wave sleep at night, use of hypnosis and benzodiazepine family of medications in some cases, providing safe environments for sleep and psychotherapy and non REM suppressing psychotropic medications.

      In fact in one review, psychotherapy was recommended to a carefully selected subgroup of patients, only one-third of group were willing to try it. However, of those patients who began psychotherapy 75 per cent rated it as beneficial.

            Pain is difficult to define as it is subjective and psychological. Probably the best definition is that it is an unpleasant experience associated with the tissue damage.

            Pain is more complex than other sensory systems such as vision or hearing as it involves transfer of sensory information to the nervous system but produces suffering which leads to aversive corrective behaviour like withdrawing from harmful agents. Thus it serves as a useful warning system.

            Pain receptors in the skin and other tissues of our body are nerve terminals which are triggered by a chemical stimulus when a potential damage occurs. Acute pain often has simple and effective treatment regimes. However, chronic pain rarely has simple solutions as it is not fully understood. It is inevitably accompanied by many psychological factors such as depression, anxiety and personal environmental interactions.

            An indirect or inferential measurement of some one’s pain may be made by means of so-called pain thresholds. There are many methods available for measuring this threshold which however are open to criticism.

            A popular method is to employ a dolorimeter which uses a heat source operated by a timing mechanism. An even safer device is a pressure algometer, a rod with a flat end loaded against a calibrated spring. Pressure applied on a flat body surface (for example, the skin) is increased steadily until pain is reported. Under controlled conditions women are more sensitive to pain (have lower thresholds) than men, office workers than manual workers, and anxious people than calm people.

            There are a number of reports of people without the ability to feel pain at all or in some cases very little. They are at a greater risk of suffering and their life expectancy is shorter than average.

            Pain is an alarm initiated upon tissue injury, carried along fairly specific nerves, and ultimately experienced according to the past experience of the sufferer. Our body has its own analgesics to relieve pain. They are a group of opiate proteins called endorphins with special pain-relieving properties. They are naturally found in the brain and are distributed throughout the nervous system. They bind to specific brain tissues involved in the perception of pain.

  All sensation from the body is carried through the spinal cord along the posterior route, says Dr. A.V. Srinivasan, an eminent neuro-physician. It consists of two divisions – medical and lateral. The medical division carries sensation such as pressure, vibration, movement, position and fine touch. The lateral division carries pain and temperature.

            When pain balms are rubbed, the pressure and movement sensations are produced in excess. This is turn sends more sensory input via the larger division of the posterior route which blocks the pain sensation through the lateral division of the posterior route to the spinal cord. The medial division blocks the pain sensation at the gate entry zone of the spinal cord. This mechanism of pain relief can be extended to acupuncture and never stimulations also, he says.

            Therapeutic measures relieve pain by increasing the level of endorphins. Pain balms generally contain 3 components – methyl salicylate, menthol and camphor. These are easily absorbed through the skin. Menthol is a white crystalline substance and a principal constituent of oil of peppermint.

            Role of the balm includes a local anesthetic effect which acts along peripheral nerve endings. These analgesics are chemically similar to endorphins and they relieve pain by binding to the same sites as endorphins. Experience of pain is psychological and subjective.

            Although these analgesics have a special pharmacological effect in relieving pain, it is actually the amount of pressure applied and the movement that plays a significant role. Also other measures that increase confidence also will ease pain.

            While methyl salicylate absorbed through the skin acts as an analgesic, menthol dilates the blood vessels. Because of the increased blood flow one gets a cool sensation in the balm- applied area. This is useful in case of headache and rheumatic pains. Camphor also acts as a rubefacient and mild analgesic.

When a person cries tear fluid is secreted by a lacrimal gland seen bulging the conjunctiva (muscous membrane covering the eyeball and lining the eyelids). This tear passes through numerous ducts into the conjunctival sac, aided by ocular muscle contraction. From there it reaches the lacrimal sac and through the lacrimal duct it is drained into the nasal cavity. (Lacrimal duct is an anatomical drainage canal connects the corner of the eye to the lower surface of the nasal cavity). When there is a sudden discharge of tear, as while crying, the fluid is pooled resulting in congestion.

            Another interesting fact is that Nature has provided a flap valve at the terminal part of the canal to prevent tear fluid from being pushed back by air, while sneezing or blowing.

A yawning is considered as a form of expression indicating boredom or a break in our train of thought. For many, it is relaxing or may occur in response to seeing someone else yawn. Nobody knows why one person yawning can cause others to yawn.

Scientists say that the question can also be asked of our primate relatives. They have presented evidence that yawns are contagious among monkeys, particularly with individuals of similar age and social status. This contagion is interpreted as a synchronization of activities ‘due to the imposition of wake-sleep rhythms on different individuals and to the attention they devote to each other’.

A yawning should be in a process of decreasing arousal according to them. If observed by other animals and if the observers arousal level becomes synchronized as a consequence the observers will also yawn. Accordingly, the yawn should be only a sufficient, not a necessary, factor in electing yawns from other group members.

Watching somebody taking a nap, in other words, might also induce a state of declining arousal and trigger yawns. One would expect observed yawns to be a more powerful stimulus, however, because another’s yawns might precipitate the observer attending to muscular tension in the facial muscles that can be dissipated by the yawn’s stretch. In addition one might expect observed stretches in general to be contagious, and yawns may thus be a particularly obvious example of the general behavioural synchrony of interact ants.

   In general, bacteria use a number of different genetic mechanisms to develop, optimize and spread the genes that give them resistance. This includes the following:

• They suddenly change their genetic information (mutation).
• They exchange plasmids. Plasmids are additional, ring-shaped deoxyribonucleic (DNA) structures in bacterial cells.
• They spread by cloning. This means that they reproduce one cell whose daughters are transferred from one person to another.

Resistance genes develop when genes in the bacterial chromosome are modified by mutation. This generally requires more than one step. Mutation normally has to take place in several genes to achieve clinically effective resistance.

The selection caused by the way antibiotics are used is contributing to the rapid pace with which resistance is increasing. Massive use of certain antibiotics can lead particularly quickly to the spread of resistant strains. Without the selection pressure exerted by antibiotics, resistance genes could develop but they would never be able to spread sufficiently to gain dominance. Individual bacteria can only become dominant if they enjoy a persistent selective advantage over the rest of the bacterial population.

            Cloning is the process of ‘deriving’ an organism or a group of cells from another organism or from a single cell asexually. Members of a clone are identical in their inherited characteristic that is, in these genes except for any differences caused by mutation. Identical twins who originate by the division of a single fertilized egg are members of a clone, whereas non identical twins that derive from two separate fertilized eggs are not, according to the Encyclopedia.

            Through recent advances of genetic engineering, scientists can isolate one or more genes from one organism and grow it in another organism belonging to a different species. The species chosen as a recipient is usually one that can reproduce asexually, such as a bacterium or yeast. Thus it is able to produce a clone of organisms, or of cell, that all contain the same foreign gene or genes. They make many copies of a particular gene.

            The copies can then be isolated and used to study. As this procedure involves clones of organisms or cells it is called cloning.

Identical twin animals can also be produced by cloning. An embryo in the early stage or development is removed from the uterus and split, and then each separate part is placed in a surrogate uterus. This method has been used to produce mice and sheep.

 Another development has been the discovery that a whole nucleus, containing an entire set of chromosomes, can be taken from a cell and injected into a fertilized egg whose own nucleus has been removed. The division of the egg brings about the division of the nucleus, and the descendant nuclei can, in their turn, be injected into eggs.

 After several such transfers, the nuclei may become capable of directing the development of eggs into complete new organisms genetically identical to the organism from which the original nucleus was taken. This cloning technique is thus, capable of producing large numbers of genetically identical individuals. Such experiments have been carried out with frogs, mice and now with sheep and monkey. 

Keloid is a scar that does not know when to stop forming, becoming large, shiny, smooth, and often pink and dome-shaped, according to The Merck Manual of Diagnosis and Therapy. It is not known why some people get overgrown scars after injuries, surgery or acne, but keloids are more common among people of black and Asian descent, so a genetic factor is suspected.

In normal scarring, after the inflammation that follows an injury subsides, scar tissue begins to form, along with tiny new blood vessels.

Cells in the skin around the injury, called fibroblasts, produce collagen, a fibrous connective tissue. As more and more of the fibers link up, the scar becomes harder. In a keloid, the process continues long after the wound is covered over, and the scar can become quite large.

Keloids are not dangerous but can be disfiguring, tender and sometimes itchy. Removal of a keloid by surgery or the use of lasers, followed by corticosteroid injections at the site, is sometimes but not always successful, and can cause even worse scarring.

            Someone with a tendency to form keloids may want to avoid plastic surgery, though doctors can sometimes use hidden incisions in facial surgery or avoid making cuts in the periphery of the face, where keloids are more likely to form.

Our body muscle tissue can be classified as skeletal, cardiac, and visceral.

–  Skeletal muscles in all instances are attached to osseous tissues (bones).

–  Cardiac muscles form the muscular body of the heart.

–  Visceral muscles are present in all hollow viscera such as gastro-intestinal tract, blood vessels, ducts of glands, respiratory, urogenital and lymphatic systems of the body.

Certain changes occur in the functions of various organs when exercise is repeated over a period of time. The magnitude of change depends on many factors, the most important being the intensity and frequency of exercise. Age and heredity also play a role. The nature of the change depends on the type of exercise, the muscles used and the previous training of the individual.

Changes that are produced by training disappear after some time if the person stops training. The primary effects of training occur in skeletal muscle. There is an increased number of capillaries in muscle tissue, leading to increased blood flow, and therefore more oxygen is brought to the muscle cells.

There is also an increase in asteriovenus oxygen difference, which means more extraction of oxygen by muscle cells and lower lactate concentration (lactate is a product from anaerobic oxidation of glycogen of our body during insufficient supply of oxygen by blood to the muscle cells which leads to the phenomenon called muscle cramp) in muscle and blood at a given work load. This indicates that the muscles depend more on aerobic mechanism – a mechanism that uses up oxygen to oxidize glycogen to carbon dioxide and water and yield energy.

Myoglobin content: Myoglobin content stores oxygen in a manner similar to that of haemoglobin inside RBC. Training increases the Myoglobin content of skeletal muscle.

            Energy Stores: There is up to a 100 per cent increase in the glycogen storage fuel of our body. A high carbohydrate diet enhances the storage glycogen in muscle. The amount of glycogen is an important factor in endurance sports eg: long distance running. It is also found that the activity of the enzyme systems required for oxidative metabolisms are also increased. This results in about a 45 per cent increase in the rate of oxidation.

Mitochondria: Size and number of mitochondria in skeletal muscle cells increases. Also there is an increase in the concentration of enzymes needed for utilization of fuel substances to obtain energy.

Continue reading “How does regular physical exercise improve our muscles?”

    A mole is a concentration of melanin pigments deposited in the inner layer of the skin (dermis). It may or may not be raised slightly above the skin surface. It is also called nevus. It is usually congenital, hence also known as birth mark.

            At times hairs grow on them. They may appear suddenly or change their size and colour suddenly. These changes may be an indication of cancer.

            Melanin pigments are found in all animals, particularly in mammals. Several physiological and congenital conditions may induce formation of melanin in animals. Hence moles are found in animals also but they cannot be seen distinctly on them due to the presence of hairs.

The scientific name of mole is Nevus. Medically the moles or nevi are instructive tumours of the skin. The term nevus denotes any congenital lesion of skin. Common acquired nevi are tan-to-brown, uniformly pigmented solid regions of elevated skin with well defined rounded borders. They are usually less than 6mm across. They are formed when single cells which are normally interspersed among basal Keratinocytes are transferred in to round to oval melanocytes called nevus cells that grow in aggregates or nests along the dermal-epidermal junction.

The nuclei of nevi cells are uniform and rounded, contain inconspicuous nucleoli and show little or no mitotic activity. The early developmental stages in nevi are called junctional nevi. When they grow in to underlying dermis as nests or cords of cells they are called compound nevi. When they are still older the epidermal nests may be lost entirely but dermal nests develop further. Now they are called dermal nevi. Clinically, compound and dermal nevi are often more elevated than junctional nevi. Although nevi are common, their clinical and histological diversity necessitates thorough knowledge of their appearance and natural evolution. Otherwise they become confused with other skin conditions notably malignant melanoma (skin cancer tumour). There are numerous clinical and histological types of nevi. The following are important ones: 1. Congenital nevi: These are present at birth and are called acquired nevi. 2.

Spindle and epitheloid cell nevi: They are red-pink nodules and contain large plump cells with pink blue cytoplasm.3. Blue nevi: These are black blue nodules and are dendritic with heavily pigmented nevus cells.4. Halo nevi: These are identical to ordinary acquired nevi but provided with lymphocytic infiltration surrounding nevus cells. So they have host immune response.

Mole consists of cells containing melanin, a dark pigment. Moles may occur at any part of the body and can number as high as forty and may be flat or raised. Colouration could be light brown to blue black. Basically moles are harmless and are just formations on the skin, like say, hair. But these are vital indications of cancer’s onset. Any change in size or colour should be taken seriously and medical attention sought.

Two sudden and involuntary contractions within the diaphragm cause hiccups. You can get hiccups if you eat too much or too fast or if you eat victuals disagreeable to your system Hiccups, occasionally, can indicate serious conditions which include pneumonia, pancreatitis, bladder irritation, uremia, stomach disorders etc. Mild ones not lasting more than thirty minutes are never cause for concern.

Granny’s gambols for mild attacks comprise holding your breath for a tolerably long spell, drinking a glass of water while holding your breath and swallowing in rapid successions three times a glass of water duly holding your breath.

If these methods do not work hold a paper bag tightly over your nose and mouth and breathe in and for a minute or two. The relatively high level of carbon dioxide in blood shall inhibit hiccups. 

Continue reading “What causes hiccups?”

Infants born with congenital heart defects turn blue and such babies are ‘blue babies’. It occurs when the blood carried to the body contains, a less than normal amount of oxygen due to congenital heart defects. The most common defect is a hole in the septum separating two ventricles (ventricular septal defect – VSD). Normally, deoxygenated blood returns from the body to right atrium from where it flows to the right ventricle. From the right ventricle deoxygenated blood flows to the lungs where it is oxygenated.

The oxygenated blood from the lungs flows to the left atrium then to the left ventricle from where it is distributed to all parts of the body. In the case of VSD, deoxygenated blood instead of flowing to the lungs from the right ventricle, flows to the left ventricle (through the septal hole) from where is distributed to the body parts. Deoxygenated blood causes the body to turn blue (oxygenated blood is red). Blue baby disease was discovered by an American cardiologist, Hellen Brooke Taussig (1898-1986).

Infants who are fed on milk containing water contaminated with high ,nitrate content turn blue and is commonly referred to as ‘Blue baby syndrome’ (BBS). The skin of infants turn blue when there is insufficient oxygen supply to the body through the blood. Nitrates reduce the oxygen carrying capacity of haemoglobin present in the red blood corpuscles (RBC). Infants of less than six months of age are more prone to BBS. Their haemoglobin has poor chemical equilibrium and hence restoration of haemoglobin cannot take place as quickly as in adults.

Atrial fibrillation is the most common sustained cardiac arrhythmia. In arrhythmia the atria beats rapidly, chaotically and ineffectively. It is a kind of heart malformation that occurs due to abnormal rhythm of the heart.

A coordinate contraction of all the heart muscles at once, which is required for the pumping cycle leads to a normal rhythm of the heart. But abnormal rhythm of the heart results from cardiac impulses that have gone wild and violent with the auricular muscle mass and ventricular muscle mass, which are respectively called Atrial fibrillation and Ventricular fibrillation.

 Since auricular muscle mass is entirely separated from the ventricular muscle mass and insulated from each other by fibrous tissue, these two fibrillations are entirely independent of each other.

 The mechanism of atrial fibrillation is identical with that of ventricular fibrillation except that the process occurs in the atrial muscle mass instead of ventricular mass. A very frequent cause of atrial fibrillation is atrial enlargement. It results due to heart valve lesions that prevent the atria from emptying adequately into the ventricles.

 In atrial fibrillation the atria become useless as primer pumps for the ventricles. Even so, blood flows positively through the atria into the ventricles and the efficiency of ventricular pumping is decreased only 20 to 30 percent.

 Therefore in contrast to the lethality of ventricular fibrillation, a person can live for months together or even years with atrial fibrillation though at a reduced efficiency of overall heart pumping. The onset of atrial fibrillation can cause palpitation. It may precipitate or aggravate cardiac failure in, patients with an abnormal heart, especially that with mitral stenos is or poor left ventricle function. 

Continue reading “What is atrial fibrillation?”

Pulse and heart beat are checked primarily to have a simple and quick assessment of the condition of the heart and other system of the body. By checking the pulse the doctor can know the rate, rhythm and wave pattern of the arterial pulse. The normal arterial pulse will have certain characteristic features and any deviation from this pattern suggests an underlying problem.

For example normal, adult resting person’s pulse rate/heart rate is around 72 beats per minute. Here the words normal, adult resting all have significance as children’s heart rate is more compared to adults and a person who did some exercise like running, cycling and swimming will have a higher pulse/heart rate compared to other persons at rest. These are all physiological variations.

 Even at rest if a person’s pulse rate grossly deviates from the beat it signifies some underlying problem. In the same way if the rate of the rhythm or wave pattern of the pulse deviates from the normal it also denotes some underlying problem. Normal heartbeat consists of two heart sounds. In addition if any other sounds or murmurs (peculiar noises heard in between or along with the heart sounds) are heard, it also signifies some problem in the heart.

The arterial pulse can be felt at several places viz near the wrist, elbow, armpit, neck, groin, popletial fossa (area behind the knee joint) and foot. The wrist and neck are the most easily accessible places for the doctor to check the pulse with little discomfort to the patient. Hence these regions are usually preferred. In certain special conditions or diseases the pulse at the other regions are also checked. 

            There is no one reason why we get more colds and flu in winter. The rhinovirus, which is responsible for up to 40 per cent of colds, cultures better at a temperature of 32 degrees C rather than the normal body temperature of 37 degrees C. However, 32 degrees C is the normal temperature of the lining of the nose, which is good news for the virus.

We do tend to be indoors more often in poorly ventilated areas during the winter and this aids the airborne transmission of the virus. Similarly, ultraviolet rays will kill viruses and this may be another factor as there is obviously much less sunlight in winter. However, it is believed that one of the biggest factors for the great increase in colds that occurs in early autumn and just after Christmas is the return of school children and students to schools and colleges.

Children and teenagers are far more susceptible to infection as their immune system learns how to combat more infections as they get older and have been exposed to more of the 200 or so viruses responsible for the common cold. Densely packed nurseries, schools and colleges provide an ideal breeding ground for viruses which then spread out into the community, aided by the cold damp weather. 

Dandruff is thought to be caused by overgrowth of yeast such as Pityrosporum ovale which live on normal skin. This overgrowth causes local irritation resulting in hyper proliferation of the cells (keratinocytes) forming the outer layer of the skin. These form scales which accumulate and are shed as dandruff flakes.

Dandruff is a condition of excessive scaliness of the scalp. There are two varieties – dry and greasy. In the dry variety, the scales are fine, thin, white or grayish, and dry or slightly greasy. Such type of hair lacks lusture. People with this type of hair will have mild to moderate itching. The scales will fall freely on the shoulders.

This dandruff will be more common in winter than in summer. It signifies exaggeration of normal exfoliation of the horny layer of the epidermis. It usually affects people with dry integument and scalp. Such people are rather reluctant to use oil, on their scalp. In the greasy variety both the scalp and the integument are oily. It diffuses all over the scalp. Later the condition also extends to other hairy regions. It may extend typically to the eyebrows, eyelids, beard and other regions. The basic defect in this case is over production and/or change in composition of the sebaceous secretion. Dandruff is common at puberty and it occurs due to endocrine disorders, familial predisposition, unbalanced diet and constipation. Effective treatments for these conditions are prescribed, in Siddha medicine, based on commonly available plant products.

Cramp is a sudden, painful, involuntary contraction of a muscle. It generally affects the legs and hands. It can occur due to various reasons such as metabolic abnormality, sever cold, lack of blood flow and mineral deficiency. All these elicit pain or other types of sensory impulses that are transmitted from the muscle to the spinal cord, thus causing reflex muscle contraction. Thus, a positive feedback mechanism occurs so that a small amount of initial irritation leads to more and more contraction until a full-blown muscle cramp ensues.

Massage helps to overcome cramp mainly by stretching the cramped muscle. In other words, it elicits what can be termed as ‘reciprocal inhibition’ of the muscle. This can at times relieve the cramp.

Cramp can occur due to localized muscle spasm. The pain or uneasiness is caused by nervous irritation due to accumulation of some ‘metabolites; or chemicals’ in that area. Massage, external compression of muscle, improves blood supply.  Helps in washing away these metabolites and thus relives the cramp. However, not all cramps can be relieved by massage. 

Myopia is defined as an eye defect where the image of the object falls before the retina of the eye. The person affected with myopia cannot see distant objects clearly, but can see objects that are close to him. Myopia is also known as short sight. It may be caused due to: Increased Anterio Posterior length of the eyeball, Increased curvature of cornea or lens, Increased refractive index of the media particularly of lens sclerosis (early cataract).

Myopia can be broadly classified into three main types: Congenital myopia: It is present since birth and may be unilateral or bilateral. Simple or developmental myopia is common type where the defect increases usually as age advances,

Pathological myopia or degenerative myopia was the condition rapidly increases and there may be high myopia up to 20 D or more. Degenerative changes occur in post segment and fundus like myopic crescent choroidal sclerosis, post staphyloma due to stretching or sclera, vitreous degeneration retinal detachment and development of nuclear cataract seen.

 Latest technologies that are available for the treatment of myopia are: Radial Keratectomy, where the problem is corrected by making a series of radial cuts around outer edges of the cornea by a handheld small blade thereby reducing corneal curvature and reduction of myopia.

Photorefractive Keratectomy, where laser rays are used to correct the defect by gently removing corneal tissues from the central area of the cornea thereby reducing the corned curvature

 Lasik procedure combined with laser where small layer of the cornea are removed microscopically and then laser rays are applied to correct the defect.