Category Scientists & Inventions

How did Albert discover vitamin C?

Read on to know how Albert Szent-Gyorgyi found a cure for scurvy, a disease caused by a lack of vitamin C.

In 1928, a Hungarian-born US biochemist, Albert Szent-Gyorgyi, isolated an unknown substance from the adrenal glands of an ox. He named it hexuronic acid.

He soon discovered that hexuronic acid could also be obtained from oranges, lemons and cabbages. One thing common to these three sources was that they were all believed to be rich in vitamin C, a substance no one had been able to isolate till then but which was known to cure scurvy.

It occurred to Szent-Gyorgyi that hexuronic acid and vitamin C might be one and the same thing. He injected hexuronic acid into some guinea pigs that had scurvy, and waited to see what would happen. If hexuronic acid were indeed the same as vitamin C, the guinea pigs would get cured. And that is exactly what happened. The animals recovered from the disease.

He wanted to repeat the experiment but he had run out of hexuronic acid. He had to get some more, but how? It was not easy to come by adrenal glands of oxen, the best source: getting it from lemons and oranges was a laborious process.

He was pondering over the problem at dinnertime when his wife served him freshly ground chilli (paprika) with his food. He had never been fond of paprika but now he looked at it with new interest. He had tested many fruits and vegetables for hexuronic acid, but not paprika. Could it give him the acid he was so desperate to get his hands on?

He took it to his laboratory and tested it for its contents – and it was then that he fell in love with the spice. It was loaded with hexuronic acid!

Within a few weeks, he produced three pounds of pure crystalline hexuronic acid. He fed it to vitamin C deficient guinea pigs and got the same results as earlier the animals recovered from scurvy. There was no difference between hexuronic acid and vitamin C.

 When Szent-Gyorgyi received the Nobel Prize for his work in 1937, ‘Time’ magazine dubbed it the ‘Paprika Prize’.

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Who invented the Trachtenberg system of mathematics?

A system of speed mathematics, it was developed by Jakow Trachtenberg when he spent long years at a concentration camp during WWII

The Trachtenberg system is a system of speed arithmetic. With this system, you can do multiplication, division, addition, subtraction and square root operations very quickly and without a calculator. Multiplication and division can be done without the use of multiplication tables. In order to learn this system, all that you need is the ability to count.

This system was developed by Jakow Trachtenberg (1888-1953), a Russian Jewish mathematician and engineer. Trachtenberg developed his unique system of mathematics when he spent long years at a concentration camp during World War II. He was surrounded by violence, disease and death. But he escaped into a world of his own-a world of numbers, logic and order. He visualised gigantic numbers to be added and he tried calculating mentally. He invented a fool-proof method that would make it possible for even a child to add thousands of numbers together without ever adding a number higher than eleven! He scribbled his theories on whatever bit of paper he could lay his hands on – wrapping paper, old envelopes. German worksheets, etc.

In 1944, he and his wife escaped to Switzerland. There, he perfected his mathematics system.

The first students to whom Trachtenberg taught his system were children especially those who were doing poorly in studies. The results were heartening and successful.

In 1950, he founded the Mathematical Institute in Zurich, where both children and adults were taught the system. The system has been thoroughly tested in Switzerland and is found to increase the self-confidence and general aptitude to study, as the students develop outstanding arithmetic abilities.

It is a fool-proof method that would make it possible for even a child to add thousands of numbers together without ever adding a number higher than eleven.

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What does Hawking’s final theory reveal about the origin of time?

In 1998, physicist Stephen Hawking asked Belgian cosmologist Thomas Hertog to work with him to develop “a new quantum theory of the Big Bang”. What started as a doctoral project for Hertog turned into an intense collaboration that continued until Hawking’s death in 2018. Their answers to the question of how the Big Bang created conditions so perfect for life is what makes the recent book On the Origin of Time: Stephen Hawking’s Final Theory.

In their quest to rethink cosmology from an observers perspective, they had to adopt the strange rules of quantum mechanics that govern the micro-world of atoms and particles. A property called superposition in quantum mechanics suggests that particles can be in several positions at the same time. Only when observed does it randomly pick a specific location. In addition, quantum mechanics also involves random jumps and fluctuations.

Quantum universe

In a quantum universe, therefore, the past and the future emerge from a number of possibilities by continuous observations. These refer to not just the observations done by us human beings, but even the environment or a single particle can “observe”. All other possibilities become irrelevant once something has been observed.

Hawking and Hertog discovered that looking back at the earliest stages of the universe through a quantum lens gave it a more Darwinian flavour of variation and selection. In this deeper level of meta-evolution, even the laws of physics change and evolve in sync with the universe that is taking shape.

Laws evolve

While cosmologists usually start by assuming initial conditions and the laws that existed at the time of the Big Bang, Hawking and Hertog suggest that the laws themselves are a result of evolution. This means that the specific set of physical laws that govern our universe can only be understood in retrospect.

When reasoning back in time, therefore, evolution focussed towards greater simplicity and lesser structure continues all the way. This forms the crux of their hypothesis, meaning that ultimately even time and physical laws would fade away.

The study of the origin of the universe over the last 100 years or so has been against the backdrop of immutable laws of nature. Hawking and Hertog suggest that it isn’t these laws themselves, but their ability to transmute that dictates terms. If future cosmological observations find evidence of this, Hawking’s final theory might well be his greatest scientific legacy.

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Why is Vijay P. Bhatkar considered a pioneer in India’s IT industry?

Have you heard of India’s first super computer, Param 8000? It was developed under the leadership of Vijay P. Bhatkar. This happened in the 80s when the U.S denied us a supercomputer. Param 8000 was the second fastest computer at that time.

Bhatkar has been awarded the Padma Bhushan, Padma Shri and Maharashtra Bhushan. He is the initiator of the electronics revolution in our country, and has authored several books and research papers.

He is the founder executive director of Centre for Development of Advanced Computing (C-DAC) and is now developing exascale supercomputing for India. These computers can analyze massive amount of data at unimaginable speed.

Bhatkar has played a key role in forming the Electronics Research and Development Centre (ER&DC) in Thiruvananthapuram, Indian Institute of Information Technology and Management, Kerala (IIITM-K), the ETH Research Laboratory and International Institute of Information Technology in Pune, Maharashtra Knowledge Corporation, and the India International Multiversity.

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Moving objects using ultrasound waves

Using artificially engineering materials, researchers achieve contactless manipulation.

Have you heard about ultrasound? As the name suggests, ultrasound corresponds to sound waves with frequencies that are higher than the upper limit of what humans can hear. While we can’t hear it, we still put it to good use, albeit in different ways.

One of the most popular ways, and one that you might have heard of, is to use ultrasound for scans. Ultrasound scans are a procedure whereby high-frequency sound waves are bounced off objects (think organs or bones) to create an image of part of the inside of the body. Commonly used to monitor the health of unborn babies during pregnancy, ultrasound waves are also employed to diagnose medical conditions.

Hands-free movement Researchers from the University of Minnesota Twin Cities have now discovered a new method that uses ultrasound waves to move objects. The study was published in Nature Communications early in December.

Even though waves have been shown to move objects before, these objects were typically very small, in the order of millimetres to nanometres. What the researchers of this study were able to achieve was to move bigger objects using ultrasound, backed by the principles of metamaterial physics.

What are metamaterials?

Materials that are engineered artificially to interact with waves such as light and sound are referred to as metamaterials. The researchers placed a metamaterial pattern on the surface of an object, which could then be steered without touches using sound.

The researchers were not only able to move an object forward using this technique, but were also able to pull it back towards the source. Even though the study only serves as a demonstration of a concept, higher frequencies of waves and different materials and object sizes are expected to be tested in the future.

The need to move things is ever-present in many fields of science and engineering, especially robotics. By exploring ultrasound waves to move objects without physical contact, the researchers have provided a new mechanism of contactless manipulation that might prove to be important in the upcoming years.

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Why is E.C.G. Sudarshan considered an outstanding scientist?

E.C.G. Sudarshan was an Indian-American physicist and author. A professor at the University of Texas, he was nominated for the Nobel Prize nine times!

He was born in Kottayam, Kerala. He had his college education in CMS College, Kottayam and Madras Christian College, Chennai. He got his PhD from the University of Rochester.

His most important discovery was the Sudarshan-Glauber quantum representation of light. Glauber was infamously awarded the Nobel Prize for this. According to Sudarshan’s own words, “The 2005 Nobel Prize for Physics was awarded for my work, but I wasn’t the one to get it.”

He challenged even Einstein’s theory that nothing can travel faster than light. This is the case of Tachyons, which are hypothetical particles and which travel faster than light. His other discoveries include the quantum Zeno effect, non- invariance groups, positive maps of density matrices and computation.

ECG Sudarshan was awarded the Padma Bhushan, in 1976. He also received the CV Raman Award. The Padma Vibhushan came to him in 2007.

In 2005, when the Physics Nobel Prize was denied to him, there was a hue and cry. Many physicists wrote to the Swedish Academy, to show their protest that Sudarshan was not awarded a share of the Prize.

Though side-lined by the Nobel Prize committee, he kept his humour alive. He was also keen on the Vedanta philosophy and often gave lectures on this.

E.C.G. Sudarshan died on 13 May 2018.

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What was invented by DF Arago in 1820?

On September 25, 1820, French physicist Francois Arago announced his discovery of an occurrence of electromagnetism. This was just one of Arago’s many contributions as he spent a lifetime for the progress of science.

It isn’t often that we come across a person who contributes significantly to a number of different fields. Such polymaths – individuals whose knowledge encompasses a wide range of subjects – have always been rare. Frenchman Dominique Francois Jean Arago was one such person in this world, as he donned the hat of a physicist. mathematician, astronomer, and politician in an eventful life.

Born in 1786 in Estagel, Roussillon, France, Arago was one of 11 children. Educated at the Municipal College of Perpignan, Arago was drawn towards mathematics from a young age. He was admitted to the Ecole Polytechnique in Paris, where he succeeded French mathematician Gaspard Monge as the chair of Analytic Geometry at the young age of 23.

Love for optics

He made his first major contributions to science in the decade that followed. Working with French engineer Augustin-Jean Fresnel, Arago was able to show that while two rays polarised in a plane can interfere with each other, two beams of light polarised perpendicular to each other cannot interfere with each other. This research led to the discovery of the laws of light polarisation.

In 1820, Arago briefly interrupted his optical work to significantly expand on electromagnetic theories. Having been invited to Geneva to witness the experiments of Danish physicist Hans Christian Oersted linking electricity to magnetism, Arago was instantly converted and developed a huge interest in the subject.

Apart from repeating the Geneva experiments at the Paris Academy, Arago also experimented on his own. He was able to demonstrate that by passing an electric current through a cylindrical spiral of wire, it could be made to behave like a magnet. The temporary magnetisation allowed it to attract iron filings, which then fell off when the current ceased. He announced this occurrence of electromagnetism on September 25, 1820.

Electromagnetic induction

Soon after, Arago discovered the principle of the production of magnetism by rotation of a nonmagnetic conductor. He was able to show that the rotation of a nonmagnetic metallic substance like copper created a magnetic effect as it produced rotation in a magnetic needle suspended over it. It was another decade before English scientist Michael Faraday explained these using his theory of electromagnetic induction in 1831.

Arago served as the director of the Paris Observatory from 1830. As an astronomer, he was among the first to explain the scintillation of stars using interference phenomena. He was also able to provide vital stimulus to young astronomers, including Frenchman Urbain Le Verrier.

“With the point of his pen”

In 1845, Arago suggested to his protege that he investigate the anomalies in the motion of Uranus. These investigations resulted in Le Verriers discovery of Neptune in 1846, and Arago best summed it up when he called Le Verrier the man who “discovered a planet with the point of his pen”. Arago backed Le Verrier in the dispute between Le Verrier and British astronomer John Couch Adams over priority in discovering Neptune and even suggested naming the planet for Le Verrier.

Amidst all his scientific endeavours, Arago also found time to back the ideas of others. Even though French photographer Louis Daguerre was struggling to sell his daguerreotype process, he was able to catch the attention of Arago, who served as the permanent secretary of the French Academy of Sciences.

Advocate for photography

Arago arranged for the first public display of daguerreotypes in January 1839 and used the buzz it created for his lobbying. He was able to get the French Parliament to grant pensions to Daguerre and Isidore Niepce, son of French inventor Nicephore Niepce, so that they could make all the steps of the photographic process public. Arago stated that “France should then nobly give to the whole world this discovery which could contribute so much to the progress of art and science” and the technical details were made public on August 19, 1839 (hence celebrated as World Photography Day).

Optics and the study of light remained close to Arago’s heart and he devised an experiment to prove the wave theory of light. In 1838, he described a test for comparing the velocity of light in air and in water or glass. The elaborate arrangements required for the experiment and his own failing eyesight, however, meant that it wasn’t performed. Shortly before Arago’s death, French physicists Hippolyte Fizeau and Leon Foucault demonstrated the retardation of light in denser media by improving on Arago’s suggested method.

For a man who spent so much of his time pursuing science, he was also able to devote to other causes as a politician. Following the July Revolution of 1830 and up until his death in 1853, Arago was active as a politician, delivering influential speeches regarding educational reform, freedom of press, and the application of scientific thought for progress. After the February Revolution of 1848, he served as the Minister of War and the Navy and used his power to abolish slavery in French colonies. Arago’s influential life highlights the fact that he always possessed the faculty to inspire and stimulate those around him and the public at large, both in the realm of science and in politics.

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Did you know the first antibiotic penicillin was discovered by accident?

Penicillin was discovered by chance by British scientist Alexander Fleming in 1929. Fleming was growing colonies of staphylococcus bacteria, the cause of a number of diseases from boils to pneumonia, in culture plates in his laboratory. One of the plates had not been covered and airborne spores settled in it and formed a mould. Fleming was about to throw away the contents when he noticed that the mould had destroyed the bacteria in the area around it.

He realised that the mould was producing a substance that was lethal to the bacteria. He also realised that the substance could be used to cure diseases caused by the bacteria. As the mould was called Penicillium notatum, he named the unknown substance ‘penicillin’. Ten years later in 1940, Howard Florey and E. B. Chaim managed to isolate penicillin in the laboratory and showed that it could be safely administered by mouth, by injection or applied directly to wounds.

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WHAT WAS INVENTED BY WALTER HUNT?

On July 25, 1854, American inventor Walter Hunt received his patent for a paper shirt collar-“Improvement in shirt collars”. This was one of Hunt’s many inventions, the more popular of which are the safety pin and the sewing machine.

When you use a safety pin or see the paper collar in a shirt do you ever stop to think about how it came to be in the first place? There are many such inventions that silently go about doing their roles effectively, without pomp and fanfare. When it concerns the safety pin or the paper collar, they are probably taking a leaf out of their inventors book. For American inventor Walter Hunt spent a lifetime inventing without becoming a household name despite his successes.

Born in 1796 in the rural part of New York, very little is known about Hunt’s early childhood. His obituary mentions that he was more interested in people and what he could do for them rather than his own welfare, right from childhood. It was a trait that he had throughout his life as he devoted himself to his dear ones, often giving away everything in his possession, even if that meant he didn’t have enough to provide for himself.

Hunt’s first patent

Hunt’s family worked in a textile mill in the town of Lowville. With his ability to provide mechanical solutions to even complex problems, Hunt was able to work with Willis Hoskins, the mill owner, inventing and patenting a machine for spinning flax and hemp. This patent, which they obtained in 1826, was Hunt’s first.

In 1833, Hunt invented a sewing machine that used a lockstitch – the first time an inventor had not tried to replicate a hand stitch with their machine. There’s reason to believe that Hunt never patented it at the time as his daughter talked him out of commercialising the device, warning that its success would leave a lot of seamstresses unemployed.

This meant that the first patent for a lockstitch sewing machine went to American inventor Elias Howe in 1846. In the aftermath, Hunt applied a patent for his sewing machine in 1853. While the Patent Office recognised Hunt’s precedence and he therefore received public credit for the invention. Howe raked in the money as his patent continued to be valid owing to certain technicalities.

Repaying a debt

Between the time he invented and patented his sewing machine, there was once a time when Hunt found himself owing a man a $15 debt. Eager to invent something that would allow him to erase the debt. Hunt is believed to have twisted an ordinary metal wire until he ended up with a device he called the “dress pin”.

Even though the idea wasn’t entirely novel and the concept can even be dated back to the Roman empire, Hunt was able to bring in innovations that made a lasting impact. With a clasp to keep the pin’s point inside a protective case and a spring at one end that forced the other end in place. Hunt’s dress pin had all the features now found today in every safety pin.

Hunt received a patent for his dress pins on April 10, 1849 and sold its rights for just $400 off his own volition. The money helped him repay his debt, even though it was only a minute fraction of the substantial fortune that his invention created.

Muslin and paper

A little over five years later, on July 24, 1854, Hunt received a patent for his paper shirt collar – “Improvement in shirt collars”. He used a base of thin white cotton muslin and pasted very thin white paper on both its sides. These collars could be pressed between heated forms to make the shape of the neck. These collars were then varnished, thereby guarding it against the effects of sweat and also allowing it to be wiped clean with a damp cloth.

Until his death in 1859, Hunt continued to invent and patent devices, which included a knife sharpener, heating stove, ice boat, fountain pen, and a reversible metallic heel for shoes, to name a few. Even though he sold the rights to most of his patents, allowing others to enjoy the financial rewards that his devices brought, he was respected and recognised as someone who had spent his entire lifetime inventing.

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